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分子生物学（花岡研究室）

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2009｜2008｜2007｜2000-2006｜

原著論文

		2006

Tsuyama, T., Inou, K., Seki, M., Seki, T., Kumata, Y., Kobayashi, T., Kimura, K., Hanaoka, F., Enomoto, T., and Tada, S.
Chromatin loading of Smc5/6 is induced by DNA replication but not by double-strand breaks.
Biochem. Biophys. Res. Commun. 351, 935-939 (2006)
Takemoto, A., Kimura, K., Yanagisawa, J., Yokoyama, S., and Hanaoka, F.
Negative regulation of condensin I by CK2-mediated phosphorylation.
EMBO J. 25, 5339-5348 (2006)
Ohkumo, T., Kondo, Y., Yokoi, M., Tsukamoto, T., Yamada, A., Sugimoto, T., Kanao, R., Higashi, Y., Kondoh, H., Tatematsu, M., Masutani, C., and Hanaoka, F.
Ultraviolet B radiation induces epithelial tumors in mice lacking pol eta and mesenchymal tumors in mice deficient for pol iota.
Mol. Cell. Biol. 26, 7696-7706 (2006)
Yuasa, M. S., Masutani, C., Hirano, A., Cohn, M. A., Yamaizumi, M., Nakatani, Y., and Hanaoka, F.
A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest.
Genes Cells 11, 731-744 (2006)
Baba, D., Maita, N., Jee, J. G., Uchimura, Y., Saitoh, H., Sugasawa, K., Hanaoka, F., Tochio, H., Hiroaki, H., and Shirakawa, M.
Crystal structure of SUMO-3-modified thymine-DNA glycosylase.
J. Mol. Biol. 359, 137-147 (2006)
Chen, Y. W., Cleaver, J. E., Hanaoka, F., Chang, C. F., and Chou, K. M.
A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents.
Mol. Cancer Res. 4, 257-265 (2006)
Fan, L., Arvai, A. S., Cooper, P. K., Iwai, S., Hanaoka, F., and Tainer, J. A.
Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair.
Mol. Cell 22, 27-37 (2006)
Ohkumo, T., Masutani, C., Eki, T., and Hanaoka, F.
Deficiency of the Caenorhabditis elegans DNA polymerase eta homologue increases sensitivity to UV radiation during germ-line development.
Cell Struct. Funct. 31, 29-37 (2006)
Kamamura-Kohno, Y., Karasawa-Shimizu, K., Saitoh, T., Sato, M., Hanaoka, F., Tanaka, S., and Ishimi, Y.
Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells.
FEBS J. 273, 1224-1239 (2006)
Martomo, S. A., Yang, W. W., Vaisman, A., Maas, A., Yokoi, M., Hoeijmakers, J. H., Hanaoka, F., Woodgate, R., and Gearhart, P. J.
Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota.
DNA Repair 5, 392-398 (2006)

		2005

Kawamoto, T., Araki, K., Sonoda, E., Yamashita, Y. M., Harada, K., Kikuchi, K., Masutani, C., Hanaoka, F., Nozaki, K., Hashimoto, N., and Takeda, S.
Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis.
Mol. Cell 20, 793-799 (2005)
Chiapperino, D., Cai, M., Sayer, J. M., Yagi, H., Kroth, H., Masutani, C., Hanaoka, F., Jerina, D. M., and Cheh, A. M.
Error-prone translesion synthesis by human DNA polymerase eta on epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
J. Biol. Chem. 280, 39684-39692 (2005)
Nakamura, M., Nabetani, A., Mizuno, T., Hanaoka, F., and Ishikawa, F.
Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha.
Mol. Cell. Biol. 25, 11073-11088 (2005)
Okuda, M., Tanaka, A., Hanaoka, F., Ohkuma, Y., and Nishimura, Y.
Structural insights into the asymmetric effects of zinc-ligand cysteine mutations in the novel zinc ribbon domain of human TFIIEalpha for transcription.
J. Biochem. (Tokyo) 138, 443-449 (2005)
Mehnati, P., Morimoto, S., Yatagai, F., Furusawa, Y., Kobayashi, Y., Wada, S., Kanai, T., Hanaoka, F., and Sasaki, H.
Exploration of “over kill effect” of high-LET Ar- and Fe-ions by evaluating the fraction of non-hit cell and interphase death.
J. Radiat. Res. (Tokyo) 46, 343-350 (2005)
O’Donovan, P., Perrett, C. M., Zhang, X., Montaner, B., Xu, Y. Z., Harwood, C. A., McGregor, J. M., Walker, S. L., Hanaoka, F., and Karran, P.
Azathioprine and UVA light generate mutagenic oxidative DNA damage.
Science 309, 1871-1874 (2005)
Kamada, K., and Hanaoka, F.
Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin.
Mol. Cell 19, 497-509 (2005)
Yagi, Y. Ogawara, D., Iwai, S., Hanaoka, F., Akiyama, M., and Maki, H.
DNA polymerases eta and kappa are responsible for error-free translesion DNA synthesis activity over a cis-syn thymine dimmer in Xenopus laevis oocyte extracts.
DNA Repair 4, 1252-1269 (2005)
Hoffman, P. D., Wang, H., Lawrence, C. W., Iwai, S., Hanaoka, F., and Hays, J. B.
Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson-Crick and novel nucleotides, in different DNA sequence contexts.
DNA Repiar 4, 983-993 (2005)
Sano, S., Chan, K. S., Kira, M., Kataoka, K., Takagi, S., Tarutani, M., Itami, S., Kiguchi, K., Yokoi, M., Sugasawa, K., Mori, T., Hanaoka, F., Takeda, J., and DiGiovanni, J.
Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation.
Cancer Res. 65, 5720-5729 (2005)
Nishi, R., Okuda, Y., Watanabe, E., Mori, T., Iwai, S., Masutani, C., Sugasawa, K., and Hanaoka, F.
Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.
Mol. Cell. Biol. 25, 5664-5674 (2005)
Baba, D., Maita, N., Jee, J.-G., Uchimura, Y., Saitoh, H., Sugasawa, K., Hanaoka, F., Tochio, H., Hiroaki, H., and Shirakawa, M.
Crystal structure of SUMO1-conjugated thymine DNA glycosylase.
Nature 435, 979-982 (2005)
Martomo, S. A., Yang, W. W., Wersto, R. P., Ohkumo, T., Kondo, Y., Yokoi, M., Masutani, C., Hanaoka, F., and Gearhart, P. J.
Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification.
Proc. Natl. Acad. Sci. USA 102, 8656-8661 (2005)
King, N. M., Nikolaishvili-Feinberg, N., Bryant, M. F., Luche, D. D., Heffernan, T. P., Simpson, D. A., Hanaoka, F., Kaufman, W. K., and Cordeiro-Stone, M.
Overexpression of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts.
DNA Reapair 4, 714-724 (2005)
Sugasawa, K., Okuda, Y., Saijo, M., Nishi, R., Matsuda, N., Chu, G., Mori, T., Iwai, S., Tanaka, K., Tanaka, K., and Hanaoka, F.
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.
Cell 121, 387-400 (2005)
Yanagi, KI, Mizuno, T., Ttsuyama, T., Tada, S., Iida, Y., Sugimoto, A., Eki, T., Enomoto, T., and Hanaoka, F.
Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.
Cell 121, 387-400 (2005)
Miyake, Y., Mizuno, T., Yanagi, KI, and Hanaoka, F.
Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation.
J. Bio. Chem. 280, 12643-12652 (2005)
Hayashi, K., Watanabe, T., Tanaka, A., Furumoto, T., Sato-Tsuchiya, C., Kimura, M., Yokoi, M., Ishihama, A., Hanaoka, F., and Ohkuma, Y.
Studies of Schizosaccharomyces pombe TFIIE indicate conformational and functional changes in RNA polymerase II at transcription initiation.
Genes Cells 10, 207-224 (2005)
Yasuda, T., Sugasawa, K., Shimizu, Y., Iwai, S., Shiomi, T., and Hanaoka, F.
Nucleosomal structure of undamaged DNA regions suppresses the non-specific DNA binding of the XPC complex.
DNA Repair 4, 389-395 (2005)
Wilson, T. M., Vaisman, A., Martomo, S. A., Sullivan, P., Lan, L., Hanaoka, F., Yasui, A., Woodgate, R., and Geahart, P. J.
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.
J. Exp. Med. 201, 637-645 (2005)

		2004

Okuda, M., Tanaka, A., Arai, Y., Satoh, M., Okamura, H., Nagadoi, A., Hanaoka, F., Ohkuma, Y., and Nishimura, Y.
A novel zinc finger structure in the large subunit of human general transcription factor TFIIE.
J. Biol. Chem. 279, 51395-51403 (2004)
Kusumoto, R., Masutani, C., Shimmyo, S., Iwai, S., and Hanaoka, F.
NA binding properties of human DNA polymerase eta: implications for fidelity and polymerase switching of translesion synthesis.
Genes Cells 9, 1139-1150 (2004)
Yasui, M., Dong, H., Bonala, R. R., Suzuki, N., Ohmori, H., Hanaoka, F., Johnson, F., Grollman, A. P., and Shibutani, S.
Mutagenic properties of 3-(deoxyguanosine-N2-yl)-2-acetylaminofluorene, a persistent acetylaminofluorene-derived DNA adduct in mammalian cells.
Biochemistry 43, 15005-15013 (2004)
Li, X., Sakashita, G., Matsuzaki, H., Sugimoto, K., Kimura, K., Hanaoka, F., Taniguchi, H., Furukawa, K., and Urano, T.
Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.
J. Biol. Chem. 279, 47201-47211 (2004)
Iwamoto, T., Kobayashi, N., Imoto, K., Yamamoto, A., Nakamura, Y., Yamauchi, Y., Okumura, H., Tanaka, A., Hanaoka, F., Shibutani, S., Miyagawa, S., and Mori, T.
In situ detection of acetylaminofluorene-DNA adducts in human cells using monoclonal antibodies.
DNA Repair 3, 1475-1482 (2004)
Okuda, Y., Nishi, R., Ng, J. M. Y., Vermeulen, W., van der Horst, G. T. J., Mori, T., Hoeijmakers, J. H. J., Hanaoka, F., and Sugasawa, K.
Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex.
DNA Repair 3, 1285-1295 (2004)
Suzuki, N., Yasui, M., Laxmi, Y. R. S., Ohmori, H., Hanaoka, F., and Shibutani, S.
Translesion synthesis past equine estrogen-derived 2’-deoxycytidine DNA adducts by human DNA polymerases eta and kappa.
Biochemistry 43, 11312-11320 (2004)
Izumi, M., Yatagai, F., and Hanaoka, F.
Localization of human Mcm10 is spatially and temporally regulated during S phase.
J. Biol. Chem. 279, 32569-32577 (2004)
Ohashi, E., Murakumo, Y., Kanjo, N., Akagi, J., Masutani, C., Hanaoka, F., and Ohmori, H.
Interaction of hREV1 with three human Y-family DNA polymerases.
Genes Cells 9, 523-531 (2004)
Suzuki, N., Itoh, S., Poon, K., Hanaoka, F., Ohmori, H., Yoshizawa, I., and Shibutani, S.
Miscoding events occurred at model estrogen-derived DNA adducts during DNA synthesis by human DNA polymerase eta and kappa.
Biochemistry 43, 6304-6311 (2004)
Katafuchi, A., Nakano, T., Masaoka, A., Terato, H., Iwai, S., Hanaoka, F., and Ide, H.
Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions.
J. Biol. Chem. 279, 14464-14471 (2004)
Niimi, A., Limsirichaikul, S., Yoshida, S., Iwai, S., Masutani, C., Hanaoka, F., Kool, E. T., Nishiyama, Y., and Suzuki, M.
Palm residue mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity.
J. Biol. Chem. 279, 14464-14471 (2004)
Murakami, C., Mizuno, T., Hanaoka, F., Yoshida, H., Sakaguchi, K., and Mizushina, Y.
Mechanism of cell cycle arrest by sulfoquinovosyl monoacylglycerol with a C18-saturated fatty acid (C18-SQMG).
Biochem. Pharmacol. 67, 1373-1380 (2004)
Takasawa, K., Masutani, C., Hanaoka, F., and Iwai, S.
Chemical synthesis and translesion replication of cis-syn cyclobutane thymine-uracil dimer.
Biochem. Pharmacol. 67, 1373-1380 (2004)
Kino, K., Shimizu, Y., Sugasawa, K., Sugiyama, H., and Hanaoka, F.
Nucleotide excision repair of 5-formyluracil in vitro is enhanced by the presence of mismatched bases.
Biochem. Pharmacol. 67, 1373-1380 (2004)
Fujiwara, K., Tenno, T., Sugasawa, K., Jee, J. G., Ohki, I., Kojima, C., Tochio, H., Hiroaki, H., Hanaoka, F., and Shirakawa, M.
Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B.
J. Biol. Chem. 279, 4760-4767 (2004)
Takemoto, A., Kimura, K., Yokoyama, S., and Hanaoka, F.
Cell cycle-dependent phosphorylation, nuclear localization, and activation of human condensin.
J. Biol. Chem. 279, 4551-4559 (2004)
McCulloch, S. D., Kokoska, R. J., Masutani, C., Iwai, S., Hanaoka, F., and Kunkel, T. A.
Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity.
Nature 428, 97-100 (2004)

		2003

Higurashi, M., Ohtsuki, T., Inase, A., Kusumoto, R., Masutani, C., Hanaoka, F., and Iwai, S.
Identification and characterization of an intermediate in the alkali degradation of (6-4) photoproduct-containing DNA.
J. Biol. Chem. 278, 51968-51973 (2003)
Ito, N., Nureki, O., Shirouzu, M., Yokoyama, S., and Hanaoka, F.
Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis.
Genes Cells 8, 913-923 (2003)
Bassett, E., Vaisman, A., Havener, J. M., Masutani, C., Hanaoka, F., and Chaney, S. G.
Efficiency of extension of mismatched primer termini across from cisplatin and oxaliplatin adducts by human DNA polymerases b and h in vitro.
Biochemistry 42, 14197-14206 (2003)
You, Z., Ishimi, Y., Mizuno, T., Sugasawa, K., Hanaoka, F., and Masai, H.
Thymine-rich single-stranded DNA sequences specifically activates mouse Mcm4/6/7 helicase on Y-fork and bubble-like substrates.
EMBO J. 22, 6148-6160 (2003)
Jaloszynski, P., Masutani, C., Hanaoka, F., Perez, A. B., and Nishimura, S.
8-Hydroxyguanine in a mutational hotspot of the c-Ha-ras gene causes misreplication, ‘action-at-a-distance’ mutagenesis and inhibition of replication.
Nucleic Acids Res. 31, 6085-6095 (2003)
Riedl, T., Hanaoka, F., and Egly, J.-M.
The comings and goings of nucleotide excision repair factors on damaged DNA.
EMBO J. 22, 5293-5303 (2003)
Vaisman, A., Frank, E. G., Iwai, S., Ohashi, E., Ohmori, H., Hanaoka, F., and Woodgate, R.
Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase i.
DNA Repair 2, 991-1006 (2003)
McDonald, J. P., Frank, E. G., Plosky, B. S., Rogozin, I. B., Masutani, C., Hanaoka, F., Woodgate, R., and Gearhart, P. J.
129-derived strains of mice are deficient in DNA polymerase i and have normal immunoglobulin hypermutation.
J. Exp. Med. 198, 635-643 (2003)
Kamada, K., Hanaoka, F., and Burley, S. K.
Crystal structure of the MazE/MazF complex. Molecular bases of antidote-toxin recognition.
Mol. Cell 11, 875-884 (2003)
Yang, I. Y., Miller, H., Wang, Z., Frank, E. G., Ohmori, H., Hanaoka, F., and Moriya, M.
Mammalian translesion DNA synthesis across an acrolen-derived deoxyguanosine adduct: Participation of DNA polymerase h in error-prone synthesis in human cells.
J. Biol. Chem. 278, 13989-13994 (2003)
Watanabe, T., Hayashi, K., Tanaka, A., Furumoto, T., Hanaoka, F., and Ohkuma, Y.
The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II.
Mol. Cell. Biol. 23, 2914-2926 (2003)
Shimizu, M., Gruz, P., Kamiya, H., Kim, S.-R., Pisani, F. M., Masutani, C., Kanke, Y., Harashima, H., Hanaoka, F., and Nohmi, T.
Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases.
EMBO Rep. 4, 269-273 (2003)
Janicievic, A., Sugasawa, K., Shimizu, Y., Hanaoka, F., Wijgers, N., Djurica, M., Hoeijmakers, J. H. J., and Wyman, C.
DNA bending by the human damage recognition complex XPC-HR23B.
DNA Repair 2, 325-336 (2003)
Shimizu, Y., Iwai, S., Hanaoka, F., and Sugasawa, K.
Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase.
EMBO J. 22, 164-173 (2003)

		2002

Bassett, E., Vaisman, A., Tropea, K. A., McCall, C. M., Masutani, C., Hanaoka, F., and Chaney, S. G.
Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases b and h.
DNA Repair 1, 1003-1016 (2002)
Servant, L., Cazaux, C., Bieth, A., Iwai, S., Hanaoka, F., and Hoffmann, J. S.
A role for DNA polymerase b in mutagenic UV lesions bypass.
J. Biol. Chem. 277, 50046-50053 (2002)
You, Z., Ishimi, Y., Masai, H., and Hanaoka, F.
Roles of Mcm7 and Mcm4 subunits in DNA helicase activity of mouse Mcm4/6/7 complex.
J. Biol. Chem. 277, 42471-42479 (2002)
Yanagi, K., Mizuno, T., You, Z., and Hanaoka, F.
Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity.
J. Biol. Chem. 277, 40871-40880 (2002)
Yamada, A., Masutani, C., and Hanaoka, F.
Detection of reduced RNA synthesis in UV-irradiated Cockayne syndrome group B cells using an isolated nuclear system.
Biochim. Biophys. Acta 1592, 129-134 (2002)
Fukumoto, Y., Hiyama, H., Yokoi, M., Nakaseko, Y., Yanagida, M., and Hanaoka, F.
Two budding yeast RAD4 homologs in fission yeast play different roles in the repair of UV-induced DNA damage.
DNA Repair 1, 833-845 (2002)
Morimoto, S., Goto, S., Kato, T., Izumi, M., Komiyama-Kobayashi, M., Fukunishi, N., Honma, M., Hanaoka, F., and Yatagai, F.
Cellular response to low dose heavy-ion exposure in human cells.
Radiat. Prot. Dosimetry 99, 253-254 (2002)
Yatagai, F., Morimoto, S., Goto, S., Kato, T., Honma, M., and Hanaoka, F.
Mutation induction in human cells after low dose X ray exposure.
Radiat. Prot. Dosimetry 99, 241-243 (2002)
Pavlov, Y. I., Rogozin, I. B., Galkin, A. P., Aksenova, A. Y., Hanaoka, F., Rada, C., and Kunkel, T. A.
Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.
Proc. Natl. Acad. Sci. USA 99, 9954-9959 (2002)
Uchida, A., Sugasawa, K., Masutani, C., Dohmae, N., Araki, M., Yokoi, M., Ohkuma, Y., and Hanaoka, F.
The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH.
DNA Repair 1, 449-461 (2002)
Hey, T., Lipps, G., Sugasawa, K., Iwai, S., Hanaoka, F., and Krauss, G.
The XPC-HR23B complex displays high affinity and specificity for damaged DNA in a true-equilibrium fluorescence assay.
Biochemistry 41, 6583-6587 (2002)
Morimoto, S., Kato, T., Honma, M., Hayashi, M., Hanaoka, F., and Yatagai, F.
Detection of genetic alterations induced by low-dose X rays: analysis of loss of heterozygosity for TK mutation in human lymphoblastoid cells.
Radiat. Res. 157, 533-538 (2002)
Kusumoto, R., Masutani, C., Iwai, S., and Hanaoka, F.
Translesion synthesis by human DNA polymerase h across thymine glycol lesions.
Biochemistry 41, 6090-6099 (2002)
Chiapperino, D., Kroth, H., Kramarczuk, I., Sayer, J. M., Masutani, C., Hanaoka, F., Jerina, D. M., and Cheh, A. M.
Preferential misincorporation of purine nucleotides by human DNA polymerase h opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts.
J. Biol. Chem. 277, 11765-11771 (2002)
Nakanishi, A., Imajoh-Ohmi, S., and Hanaoka, F.
Characterization of the interaction between GyrI (DNA gyrase inhibitor) and DNA gyrase of Escherichia coli.
J. Biol. Chem. 277, 8949-8954 (2002)
Wada, M., Miyazawa, H., Wang, R.-S.,Mizuno, T., Sato, A., Asashima, M., and Hanaoka, F.
The second subunit of mouse DNA polymerase e, DPE2, interacts with SAP18 and recruits the Sin3 Co-repressor protein to DNA.
J. Biochem. (Tokyo) 131, 307-311 (2002)
Ng, J. M., Vrieling, H., Sugasawa, K., Ooms, M. P.,. Grootegoed, J. A., Vreeburg, J. T. M., Visser, P., Beems, R. B., Gorgels, T. G. M. F., Hanaoka, F., Hoeijmakers, J. H. J., and van der Horst, G. T. J.
Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B.
Mol. Cell. Biol. 22, 1233-1245 (2002)
Sugasawa, K., Shimizu, Y., Iwai, S., and Hanaoka, F. (2002) A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex.
Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B.
DNA Repair 1, 95-107 (2002)
Broughton, B. C., Cordonier, A., Kleijer, W. J., Jaspers, N. G., Fawcett, H., Raams, A., Garritsen, V. H., Stary, A., Avril, M. F., Boudsocq, F., Masutani, C., Hanaoka, F., Fuchs, R. P., Sarasin, A., and Lehmann, A. R.
Molecular analysis of mutations in DNA polymerase h in xeroderma pigmentosum-variant patients.
Proc. Natl. Acad. Sci. USA 99, 815-820 (2002)

		2001

Yatagai, F., Nohmi, T., Kusakabe, M., Masumura, K., Yoshiki, A., Yamaguchi, H., Kurobe, T., Kuniya, K., Hanaoka, F., and Yano, Y.
Mutation induction by heavy-ion irradiation of gpt delta transgenic mice.
Pjys. Med. 17, 192-193 (2001)
Kuraoka, I., Robins, P., Masutani, C., Hanaoka, F., Gasparutto, D., Cadet, J., Wood, R. D., and Lindahl, T.
Oxygen free-radical damage to DNA: translesion synthesis by DNA polymerase h and resistance to exonuclease action at cyclopurine deoxynucleoside residues.
J. Biol. Chem. 276, 49283-49288 (2001)
Izumi, M., Yatagai, F., and Hanaoka, F.
Cell cycle-dependent proteolysis and phosphorylation of human Mcm10.
J. Biol. Chem. 276, 48526-48531 (2001)
Ito, N., Nureki, O., Shirouzu, M., Yokoyama, S., and Hanaoka, F.
Crystallization and preliminary X-ray analysis of a DNA primase from the hyperthermophilic archaeon, Pyrococcus horikoshii.
J. Biochem. (Tokyo) 130, 727-730 (2001)
Katsumi, S., Kobayashi, N., Imoto, K., Nakagawa, A., Yamashina, Y., Muramatsu, T., Shirai, T., Miyagawa, S., Sugiura, S., Hanaoka, F., Matsunaga, T., Nikaido, O., and Mori, T.
In situ visualization of ultraviolet-light-induced DNA damage repair in locally irradiated human fibroblasts.
J. Invest. Dermatol. 117, 1156-1161 (2001)
Boudsocq, F., Iwai, S., Hanaoka, F., and Woodgate, R.
Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic polh.
Nucleic Acids Res. 29, 4607-4616 (2001)
Matsuda, T., Bebenek, K., Masutani, C., Rogozin, I. B., Hanaoka. F., and Kunkel, T. A.
Error rate and specificity of human and murine DNA polymerase h.
J. Mol. Biol. 312, 335-346 (2001)
Levine, R. L., Miller, H., Grollman, A., Ohashi, E., Ohmori, H., Masutani, C., Hanaoka, F., and Moriya, M.
Translesion DNA synthesis catalyzed by human pol h and pol k across 1,N6-ethenodeoxyadenosine.
J. Biol. Chem. 276, 18717-18721 (2001)
Araki, M., Masutani, C., Takemura, M., Uchida, A., Sugasawa, K., Kondoh, J., Ohkuma, Y., and Hanaoka, F.
Centrosome protein centrin2/caltractin1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair.
J. Biol. Chem. 276, 18665-18672 (2001)
Ishikawa, T., Uematsu, N., Mizukoshi, T., Iwai, S., Iwasaki, H., Masutani, C., Hanaoka, F., Ueda, R., Ohmori, H., and Todo, T.
Mutagenic and non-mutagenic bypass of DNA lesions by Drosophila DNA polymerases dpolh and dpoli.
J. Biol. Chem. 276, 15155-15163 (2001)
Kusumoto, R., Masutani, C., Sugasawa, K., Iwai, S., Araki, M., Uchida, A., Mizukoshi, T., and Hanaoka, F.
Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro.
Mutation Res. 485, 219-227 (2001)
Ura, K., Araki, M., Saeki, H., Masutani, C., Ito, T., Iwai, S., Mizukoshi, T., Kaneda, Y., and Hanaoka, F.
ATP-dependent chromatin remodeling facilitates nucleotide excision repair of UV-induced DNA lesions in synthetic dinucleosomes.
EMBO J. 20, 2004-2014 (2001)
Sugasawa, K., Okamoto, T., Shimizu, Y., Masutani, C., Iwai, S., and Hanaoka, F.
Multi-step recognition mechanism in the global genomic nucleotide excision repair.
Genes Dev. 15, 507-521 (2001)
Mehnali, P., Yatagai, F., Tsuzuki, T., Hanaoka, F., and Sasaki, H.
Judgement on “hit or non-hit” of CHO cells exposed to accelerated heavy-ions (Fe- or Ar-ions) using division delay and CR-39 plastics as an indicator.
Fukuoka Igaku Zasshi 92, 46-57 (2001)
Nishikawa, N. S., Izumi, M., Yokoi, M., Miyazawa, H., and Hanaoka, F.
E2F regulates growth-dependent transcription of genes encoding both catalytic and regulatory subunits of mouse primase.
Genes Cells 6, 57-60 (2001)
McDonald, J. P., Tissier, A., Frank, E. G., Iwai, S., Hanaoka, F., and Woodgate, R.
DNA polymerase iota and related rad30-like enzymes.
Philos. Trans. R. Soc. Lond. B Biol. Sci. 356, 53-60 (2001)
Bebenek, K., Matsuda, T., Masutani, C., Hanaoka, F., and Kunkel, T. A.
Proofreading of DNA polymerase h-dependent replication errors.
J. Biol.Chem. 276, 2317-2320 (2001)
Yamamoto, S., Watanabe, Y., van der Spek, P., Watanabe, T., Fujimoto, H., Hanaoka, F., and Ohkuma, Y.
Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation.
Mol. Cell. Biol. 21, 1-15 (2001)
Kannouche, P., Broughton, B. C., Volker, M., Hanaoka, F., Mullenders, L. H. F., and Lehmann, A. R.
Domain structure, localization and function of DNA polymerase h, defective in xeroderma pigmentosum variant cells.
Genes Dev. 15, 158-172 (2001)

		2000

Izumi, M., Yanagi, K., Mizuno, T., Yokoi, M., Kawasaki, Y., Moon, K.-Y., Hurwitz, J., Yatagai, F., and Hanaoka, F.
The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G2 phase.
Nucleic Acids Res. 28, 4769-4777 (2000)
Tissier, A., Frank, E. G., McDonald, J. P., Iwai, S., Hanaoka, F., and Woodgate, R.
Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase i.
EMBO J. 19, 5259-5266 (2000)
Mizushina, Y., Kamisuki, S., Mizuno, T., Takemura, M., Asahara, H., Linn, S., Yamaguchi, M., Matsukage, A., Hanaoka, F., Yoshida, S., Saneyoshi, M., Sugawara, F., and Sakaguchi, K.
Dehydroaltenusin: A mammalian DNA polymerase alpha inhibitor.
J. Biol. Chem. 275, 33957-33961 (2000)
Yatagai, F., Nohmi, T., Kusakabe, M., Masumura, K., Yoshiki, A., Yamaguchi, H., Kurobe, T., Kuniya, K., Hanaoka, F., and Yano, Y.
Mutation induction by heavy ion irradiation of gpt delta transgenic mice.
Biol. Sci. Space 14, 172-173 (2000)
Miao, F., Bouziane, M., Dammann, R., Masutani, C., Hanaoka, F., Pfeifer, G. P., and O'Connor, T. R.
3-methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.
J. Biol. Chem. 275, 28433-28438 (2000)
Yuasa, M., Masutani, C., Eki, T., and Hanaoka, F.
Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene.
Oncogene 19, 4721-4728 (2000)
Yamada, A., Masutani, C., Iwai, S., and Hanaoka, F.
Complementation of defective translesion synthesis and ultraviolet light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase h.
Nucleic Acids Res. 28, 2473-2480 (2000)
Ohashi, E., Ogi, T., Kusumoto, R., Iwai, S., Masutani, C., Hanaoka, F., and Ohmori, H.
Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa.
Genes Dev. 14, 1589-1594 (2000)
Izumi, M., Yokoi, M., Nishikawa, N., Miyazawa, H., Sugino, A., Yamagishi, M., Yamaguchi, M., Matsukage, A., Yatagai, F., and Hanaoka, F.
Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase a is controlled by E2F, an Ets-related transcription factor, and Sp1.
Biochim. Biophys. Acta 1492, 341-352 (2000)
Masutani, C., Kusumoto, R., Iwai, S., and Hanaoka, F.
Mechanisms of accurate translesion synthesis by human DNA polymerase h.
DNA Repair 5, 392-398 (2000)
Watanabe, Y., Fujimoto, H., Watanabe, T., Maekawa, T., Masutani, C., Hanaoka, F., and Ohkuma, Y.
Modulation of TFIIH-associated kinase activity by complex formation and its relationship with CTD phosphorylation of RNA polymerase II.
Genes Cells 5, 407-423 (2000)
Nishikawa, N. S., Izumi, M., Uchida, H., Yokoi, M., Miyazawa, H., and Hanaoka, F.
Cloning and characterization of the 5'-upstream sequence governing the cell cycle-dependent transcription of mouse DNA polymerase a-p 68-kDa subunit gene.
Nucleic Acids Res. 28, 1525-1534 (2000)
Vaisman, A., Masutani, C., Hanaoka, F., and Chaney, S. G.
Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase h.
Biochemistry 39, 4575-4580 (2000)
Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., and Kunkel, T. A.
Low fidelity DNA synthesis by human DNA polymerase h.
Nature 404, 1011-1013 (2000)
Araki, M., Masutani, C., Maekawa, T., Watanabe, Y., Yamada, A., Kusumoto, R., Sakai, D., Sugasawa, K., Ohkuma, Y., and Hanaoka, F.
Reconstitution of damage DNA excision reaction from SV40 minichromosomes with purified nucleotide excision repair proteins.
Mutation Res. 459, 147-160 (2000)
Okuda, M., Watanabe, Y., Okamura, H., Hanaoka, F., Ohkuma, Y., and Nishimura, Y.
Structure of the central core domain of TFIIEb with a novel double-stranded DNA-binding surface.
EMBO J. 19, 1346-1356 (2000)
Yokoi, M., Masutani, C., Maekawa, T., Sugasawa, K., Ohkuma, Y., and Hanaoka, F.
The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA.
J. Biol. Chem. 275, 9870-9875 (2000)

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総説

		2000-2006

	Kamath-Loeb, A. S., Loeb, L. A., Masuda, Y., and Hanaoka, F. The first US-Japan meeting on error-prone DNA synthesis, Maui, Hawaii, December 20-21, 2004. DNA Repair 4, 740-747 (2005) Katafuchi, A., Matsubara, M., Terato, H., Iwai, S., Hanaoka, F., and Ide, H. Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions. Nucleic Acids Symp. Ser. (Oxf) 48, 175-176 (2004) Kino, K., Ito, N., Sugasawa, K., Sugiyama, H., and Hanaoka, F. Translesion synthesis by human DNA polymerase eta across oxidative products of guanine. Nucleic Acids Symp. Ser. (Oxf) 48, 171-172 (2004) Friedberg, E. C., Hanaoka, F., Tanaka, K., Wilson, S. H., and Yasui, A. Report on the First US-Japan DNA Repair Meeting. Sendai, Japan, October 27-31, 2002. DNA Repair 2, 639-652 (2003) Ahmad, S. I., Hanaoka, F., and Kirk, S. H. Molecular biology of Fanconi anaemia ? an old problem, a new insight. BioEssays 24, 439-448 (2002) Burgers, P. M., Koonin, E. V., Bruford, E., Blanco, L., Burtis, K. C., Christman, M. F., Copeland, W. C., Friedberg, E. C., Hanaoka, F., Hinkle, D. C., Lawrence, C. W., Nakanishi, M., Ohmori, H., Prakash, L., Prakash, S., Reynaud, C. A., Sugino, A., Todo, T., Wang, Z., Weill, J. C., and Woodgate, R. Eukaryotic DNA polymerases: proposal for a revised nomenclature. J. Biol. Chem. 276, 43487-43490 (2001) Ohmori, H., Friedberg, E. C., Fuchs, R. P. P., Goodman, M. F., Hanaoka, F., Hinkle, D., Kunkel, T. A., Lawrence, C. W., Livneh, Z., Nohmi, T., Prakash, L., Prakash, S., Todo, T., Walker, G. C., Wang, Z., and Woodgate, R. The Y-family of DNA polymerases. Mol. Cell 8, 7-8 (2001) Hanaoka, F. SOS polymerases. Nature 409, 33-34 (2001) Masutani, C., Kusumoto, R., Yamada, A., Yuasa, M., Araki, M., Nogimori, T., Yokoi, M., Eki, T., Iwai, S., and Hanaoka, F. Xeroderma pigmentosum variant: From a human genetic disorder to a novel DNA polymerase. Cold Spring Harbor Symp. Quant. Biol. 65, 71-80 (2000)