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生命科学プロジェクト

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2008年分
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2008年分

<学術論文>
1
Inaki, M., Utsugi, T., Onoda, F., Hanaoka, F., and Murakami, Y (2008) A novel class of temperature-sensitive mutants generated by RNAi-mediated knockdowns. Biochem. Biophys. Res. Commun. 365: 472-477
2
Yatagai, F., Umebayashi, Y., Homma, M., Sugasawa, K., Takayama, Y., and Hanaoka, F. (2008) Mutagenic radioadaptation in a human lymphoblastoid cell line. Mutat. Res. 638: 48-55
3
Hidaka, K., Yamada, M., Kamiya, H., Masutani, C., Harashima, H., Hanaoka, F., and Nohmi, T. (2008) Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta DNA Repair 7: 497-506
4
Yasui, M., Suenaga, E., Koyama, N., Masutani, C., Hanaoka, F., Gruz, P., Shibutani, S., Nohmi, T., Hayashi, M., and Honma, M. (2008) Miscoding properties of 2'-deoxyinosine, a nitric oxide-derived DNA adduct, during translesion synthesis catalyzed by human DNA polymerases. J. Mol. Biol. 377: 1015-1023
5
Tsuji, Y., Watanabe, K., Araki, K., Shinohara, M., Yamagata, Y., Tsurimoto, T., Hanaoka, F., Yamamura, K., Yamaizumi, M., and Tateishi, S. (2008) Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. Genes Cells 13: 343-354
6
Martomo, S.A., Saribasak, H., Yokoi, M., Hanaoka, F., and Gearhart, P.J. (2008) Reevaluation of the role of DNA polymerase theta in somatic hypermutation ofimmunoglobulin genes. DNA Repair 7: 1603-1608
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Ouchida, R., Ukai, A., Mori, H., Kawamura, K., Dolle, M.E., Tagawa, M., Sakamoto, A., Tokuhisa, T., Yokosuka, T., Saito, T., Yokoi, M., Hanaoka, F., Vijg, J., and Wang, J.Y. (2008) Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A:T mutations. DNA Repair 7: 1392-1398
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Ohtsu, M., Kawate, M., Fukuoka, M., Gunji, W., Hanaoka, F., Utsugi, T., Onoda, F., and Murakami, Y. (2008) Novel DNA microarray system for analysis of nascent mRNAs. DNA Res. 15: 241-251
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Fukumoto, Y., Dohmae, N., and Hanaoka, F. (2008) Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box. Mol. Cell. Biol. 28: 6746-6756
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Masuda, K., Ouchida, R., Yokoi, M., Hanaoka, F., Azuma, T., and Wang, J.Y. (2008) DNA polymerase eta is a limiting factor for A:T mutations in Ig genes and contributes to antibody affinity maturation. Eur. J. Immunol. 38: 2796-2805
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Nakamura, T., Sakai, M., Sadakane, Y., Haga, T., Goto, Y., Kinouchi, T., Saito, T., and Fujii, N. (2008) Differential rate constants of racemization of aspartyl and asparaginyl residues in human α-crystallin mutants. Biochim. Biophys. Acta 1784: 1192-1199
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Hashimoto, Y., Morisawa, K., Saito, H., Jojima, E., Yoshida, N., and Haga, T. (2008) Muscarinic M4 receptor recycling requires a motif in the third intracellular loop. J. Pharmacol. Exp. Therapeu. 325: 947 - 953
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Uehara, R., Hosoya, H., and Mabuchi, I. (2008) In vivo phosphorylation of regulatory light chain of myosin II in sea urchin eggs and its role in controlling myosin localization and function during cytokinesis. Cell Motil. Cytoskelet., 65: 100-115
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Shimi, T., Pfleghaar, K., Kojima, S., Pack, C., Solovei, I., Adam, S.A., Shumaker, D.K., Goldman, A.E., Kinjo, M., Cremer, T., and Goldman, R.D. (2008) The A-type and B-type lamin networks: microdomains involved in chromatin organization and transcription. Genes Dev. 22: 3409-3421
15
Matsuda, C., Kameyama, K., Suzuki, A., Mishima, W., Yamaji, S., Okamoto, H., Nishino, I. and Hayashi, K.Y. (2008) Affixin activates Rac1 via βPIX in C2C12 myoblast. FEBS Lett. 582: 1189-1196
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Aoki, G., Yamada, T.K., Arii, M., Kojima, S. and Mizoguchi, T. (2008) Requirement of Ala residues at g position in heptad sequence of α-helix-forming peptide forformation of fibrous structure. J. Biochem. 144: 15-19
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Usui, T., Ban, H. S., Kawada, J., Hirokawa, T., and Nakamura, H. (2008) Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening. Bioorg. Med. Chem. Lett. 18: 285-288
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Lee, C.-H., Jin, G. F., Yoon, J. H., Jung, Y. J., Lee, J.-D., Cho, S., Nakamura, H., and Kang, S.O. (2008) Synthesis and characterization of polar functional group substituted mono- and bis-(o-carboranyl)-1,3,5-triazine derivatives. Tetrahedron Lett. 49: 159-164
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Uno, M., Ban, H. S., Nabeyama, W., and Nakamura, H. (2008) De novo design and synthesis of N-benzylanilines as new candidates for VEGFR tyrosine kinase inhibitors. Org. Biomol. Chem. 6: 979-981
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Nakamura, H., Ishikura, M., Sugiishi, T., Kamakura, T., and Biellmann, J.-F. (2008) Synthesis of mono- and 1,3-disubstituted allenes from propargylic amines via palladium-catalysed hydride-transfer reaction. Org. Biomol. Chem. 6: 1471-1477
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Nakamura, H., Saito, H., and Nanjo, M. (2008) Synthesis of 1,2-dihydroisoquinolines via palladium (0)-catalysed addition-cycloaddition of pronucleophiles to ortho-alkynylaldimines. Tetrahedron Lett. 49: 2697-2700
22
Nakamura, H., Lee, J.-D., Ueno, M., Miyajima, Y., and Ban, H.S. (2008) Synthesis of closo-dodecaboryl lipids and their liposomal formation for boron neutron capturetherapy. NanoBiotechnology (invited) 3: 135-145
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Ban, H. S., Onagi, S., Uno, M., Nabeyama, W., and Nakamura, H. (2008) Allene as an alternative functional group for drug design: effect of C-C multiple bonds conjugated with quinazolines on EGFR tyrosine kinase inhibition. ChemMedChem. 3: 1094-1103
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Sogabe, N., Oda, K., Nakamura, H., Orimo, H., Watanabe, H., Hosoi, T., and Goseki-Sone, M. (2008) Molecular effects of the tissue-nonspecific alkaline phosphatase gene polymorphism (787T>C) associated with bone mineral density. Biomed. Res. 29: 213-219
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Ryu, I., Matsubara, H., Nakamura, H., and Curran, D.P. (2008) Phase-vanishing methods based on fluorous phase screen. A simple way for efficient execution of organic synthesis. Chem. Rec. 8: 351-363
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Nakamura, H., Sugiishi, T., and Tanaka, Y. (2008) Synthesis of allenes via CuBr-catalyzed homologation of alk-1-ynes accelerated by microwave. Tetrahedron Lett. 49: 7230-7233
27
Yajima, J., Mizutani, K., and Nishizaka, T. (2008) A torque component present in kinesin-5 revealed by 3D tracking. Nature Struct. Mol. Biol. 15: 1119-1121
28
Masaike, T., Koyama-Horibe, F., Oiwa, K., Yoshida, K., and Nishizaka, T. (2008) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80° and 40° substep rotations. Nature Struct. Mol. Biol. 15: 1326-1333
  

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